Early Neurovascular Adaptations in Aging Women
University of Missouri-Columbia
Summary
Our goal is to enhance our understanding of early vascular adaptations in aging women with an emphasis on the sympathetic nervous system.
Eligibility
- Age range
- 18–70 years
- Sex
- Female
- Healthy volunteers
- Yes
Inclusion Criteria: * Assigned female at birth (AFAB) * 18-70 years of age Exclusion Criteria: * Assigned male at birth (AMAB) * Pregnancy, breastfeeding * Body mass index ≥30 kg/m2 * Taking medications known to affect metabolic, autonomic, and/or respiratory function * Oral hormonal contraception in last 6 month * History of hormone replacement therapy * History of hyster- or oophor-ectomy * Current smoking/Nicotine use * Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy * Chronic disease * Blood pressure ≥140/90 mmHg * Communication barriers
Interventions
- DrugNorepinephrine
Infused intra-arterially in a dose-response fashion
- DrugIsoproterenol
Infused intra-arterially in a dose-response fashion
- DrugAcetylcholine
Infused intra-arterially in a dose-response fashion
- DrugNitroprusside
Infused intra-arterially in a dose-response fashion
- DrugEstrogen
Infused intra-arterially
Location
- University of Missouri-ColumbiaColumbia, Missouri