DISCOVERY of Risk Factors for Type 2 Diabetes in Youth
George Washington University
Summary
The goal of the DISCOVERY study is to provide innovative critical information regarding the unique natural history of glycemic control, insulin sensitivity, and β-cell function, and their mechanistic determinates, in obese adolescents at risk for developing type 2 diabetes.
Description
The DISCOVERY study will extensively phenotype a large cohort of youth at-risk for type 2 diabetes, as they transition through puberty, and characterize the course of dysfunction in pathophysiological indicators that lead to type 2 diabetes. The knowledge gained from this study of the pathophysiology and epidemiology of youth-onset type 2 diabetes with deep biochemical, clinical, and psychosocial phenotyping will critically inform the design and testing of future treatment and prevention approaches.
Eligibility
- Age range
- 8–15 years
- Sex
- All
- Healthy volunteers
- Not specified
Inclusion Criteria: Screening will occur to enrich the yield of individuals who are highly predisposed to develop youth-onset T2D and include those with all of the following criteria: * Overweight or obesity with BMI ≥85th percentile * Age 8-13 year for girls, 9-15 year for boys (inclusion younger for girls as puberty tends to start a year earlier in girls) * Tanner Stage 2, 3, or 4 * Elevated HbA1c 5.5-6.4% Exclusion Criteria: An individual who meets any of the following criteria will be excluded from participation: * Diabetes based on history, or HbA1c ≥6.5% in the medical record or at…
Locations (20)
- University of Alabama at BirminghamBirmingham, Alabama
- Arizona State UniversityPhoenix, Arizona
- Phoenix Children'sPhoenix, Arizona
- Children's Hospital Los AngelesLos Angeles, California
- Children's Hospital ColoradoAurora, Colorado
- Johns Hopkins All Children's HospitalSt. Petersburg, Florida