Mi-SPA: Michigan Split-belt Adaptation Paradigm to Improve Knee Loading After Anterior Cruciate Ligament Reconstruction (Aim 3)
University of Michigan
Summary
The goal of this study is to gather pilot data to help inform a future clinical trial. As such, the investigators will employ a randomized clinical trial design, but data will only be collected on 9 total subjects. Nine subjects will be randomized to 2 split-belt intervention groups (one group where early stance loading is trained and the other where midstance loading is trained) and a placebo group. The goal of this study is to explore the adaptations in knee loading from a 6-week split-belt training intervention. The investigators' main question for this aim is: 1. Does knee loading, measured by the sagittal plane knee moment, change to a greater extent in the split-belt treadmill training groups compared to the placebo group? 2. Are there differences in training-related knee loading changes between individuals trained in the early stance vs. midstance loading split-belt training?
Description
It is commonplace for individuals after anterior cruciate ligament (ACL) reconstruction to shift mechanical demands away from their surgical knee and limb. This manifests as diminished knee moments and vertical ground reaction forces in the ACL limb during everyday tasks (e.g., walking, running, standing, landing, etc.) and persists for as long as 2.5 years after surgery. This pattern of underloading is considered maladaptive, as it has been linked to re-injury and biological markers that are consistent with the development of post-traumatic osteoarthritis that affects over 50% of knees 10-20…
Eligibility
- Age range
- 14–45 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * aged 14-45 years * suffered an acute, complete ACL rupture as confirmed by MRI and physical exam * have undergone ACL reconstruction w autograft within the past 10 months * willingness to participate in testing and follow-up as outlined in the protocol * English-speaking Exclusion Criteria: * inability to provide written informed consent * female subjects who are pregnant or are planning to become pregnant (self-reported) * previous ACL injury * previous surgery to either knee * bony fracture accompanying ACL injury * patients who experienced a knee dislocation * patie…
Interventions
- BehavioralPlacebo Split-Belt Training
Walking on a split-belt treadmill in which the belt under the ACL leg will move at a speed that is minimally slower than the other belt.
- BehavioralSplit-Belt Training
Walking on a split-belt treadmill in which the treadmill belt under the ACL leg will move at a speed faster or slower than the belt under the Non-ACL leg.
Location
- University of MichiganAnn Arbor, Michigan