Measuring Brain Health Using Low-Field Portable MRI
Yale University
Summary
The purpose of this study is to develop a new grading scale and utilize automated segmentation for measurement of White Matter Hyperintensity (WMH) volume using a low field MRI.
Description
This study will take place in one visit, if feasible. This visit will take approximately 2 hours. (Alternatively, the visit can be split over two visits if the subject cannot tolerate two consecutive scans. The pMRI and 3T MRI can occur up to one month apart.) The purpose of this study is to create both a qualitative lowfield WMH scale that can be used widely and a machine learning enabled quantitative measurement of WMH for more sophisticated applications. To ensure the reliability of these WMH measurement systems, participants will receive both a pMRI and high-field 3T MRI at a single study…
Eligibility
- Age range
- 50+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * One vascular risk factor, from the following: 1. Hypertension (defined as taking an antihypertensive medication) 2. Hyperlipidemia (defined as taking a statin or PCSK9 inhibitor) 3. Diabetes (defined as taking a medication to prevent hyperglycemia) Exclusion Criteria: * 1\. History of stroke * History of dementia or other cognitive impairment * Pacemaker or other MRI contraindications according to the American College of Radiology guidelines
Interventions
- DevicePortable low-field MRI (pMRI)
Participants will receive a pMRI during the study visit.
- Device3T MRI
Gold standard MRI for WMH. Participants will receive a 3T MRI during the study visit.
Location
- Yale Magnetic Resonance Research Center (MRRC) at The Analyn Center (TAC)New Haven, Connecticut