18F-Fluoroestradiol (FES) Positron Emission Tomography for the Detection and Treatment Response Monitoring in Patients With Metastatic Lobular Breast Carcinoma
Memorial Sloan Kettering Cancer Center
Summary
The purpose of this study to compare two types of cancer imaging scans to see which is better at detecting and monitoring metastatic ILC. This study will compare PET/CT (positron emission tomography/computed tomography) scans using the radiotracer fluorine 18 (18F)-fluoroestradiol (FES) with a standard imaging approach for detecting and monitoring ILC, PET/CT scans using the radiotracer 18F-fluorodeoxyglucose (FDG). These scans will be referred to as FES PET/CT scans and FDG PET/CT scans.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Adult patient \> 18 years old * Biopsy-proven metastatic ILC * Confirmed ER+ breast cancer from either primary tumor or metastatic biopsy (ER receptor percent staining ≥ 10% of tumor cells by IHC) * HER2-negative per ASCO/CAP * ECOG Performance Status Score of 0, 1 or 2. * Patient can have received up to 2 lines of therapy in the metastatic setting * Life expectancy of at least 12 months Exclusion Criteria: * Low ER expression defined as ER \<10% of tumor cells by IHC * Patients who have been on adjuvant ER-blocking endocrine therapy with SERM or SERD without an 8- and…
Interventions
- Diagnostic Test18F-Fluoroestradiol PET/CT
Scanned at baseline and again posttreatment within 2 weeks of the restaging FDG PET/CT
Locations (7)
- Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities)Basking Ridge, New Jersey
- Memorial Sloan Kettering Monmouth (Limited protocol activities)Middletown, New Jersey
- Memorial Sloan Kettering Bergen (All Protocol Activities)Montvale, New Jersey
- Memorial Sloan Kettering Suffolk-Commack (All protocol activity)Commack, New York
- Memorial Sloan Kettering Westchester (Limited Protocol Activities)Harrison, New York
- Memorial Sloan Kettering Cancer Center (All Protocol Activities)New York, New York