Randomized Controlled Study Comparing the Administration of Opioids Epidurally vs IV in Patients Undergoing Laparotomy With an Epidural for Post-Operative Analgesia
University of Iowa
Summary
The purpose of this research study is to determine if the two common ways of administering additional opioids (morphine like substance, narcotic) with an epidural, either mixed in the epidural solution or given separately through the intravenous, are equally effective in controlling post-operative pain
Description
Open label, observer and patient blinded randomized control study of patients age 18 to 85 who are booked to have an open upper abdominal surgical incision where an epidural would normally be offered and expected to be used for an average of 4 to 5 days. Study will be done at University of Iowa Hospitals and Clinics main operating room and post-operative surgical wards. Eligible patients who choose to consent to participate in the study will be randomized to either have the opioid administered intravenously using patient controlled administration (PCA) device along with a local anesthetic on…
Eligibility
- Age range
- 18–85 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1. Age including and between 18 to 85 years old 2. Planned open abdominal procedure with an incision that is or includes above the umbilicus, where epidural would normally be offered and epidural would be maintained for an average of 4 to 5 days 3. Patient has consented for an epidural 4. Patient is able to converse in English 5. Patient is able to use a patient controlled pump Exclusion Criteria: 1. Has a known contraindication for an epidural 2. Known mental or cognitive disability 3. History of chronic opioid use or substance abuse disorder 4. Pre-operative use of opi…
Interventions
- DrugIntravenous administered opioid
Hydromorphone will be received intravenously using a patient controlled administration pump, as well as patient will have a continuous bupivacaine epidural infusion
- DrugEpidural administered opioid
Hydromorphone will be added to the bupivacaine in the epidural and will have a continuous infusion along with the ability for the patient to receive epidural boluses of the medications by a patient controlled epidural administration pump
Location
- University of Iowa Health CareIowa City, Iowa