Personalizing Multifocal Transcranial Direct Stimulation Dose to Target the Motor Network in Older Adults
University of Michigan
Summary
The purpose of this study is to understand how the brain controls movement and how Non-invasive Brain Stimulation (NIBS) with a technique called High-density transcranial direct current stimulation (HD-tDCS) can alter brain processes to improve behavior. Participants in this study will be randomized to either HD-tDCS with standard intervention or personalized dose-controlled multifocal network-targeted HD-tDCS. The hypothesis is that dexterous hand function will improve after a standard HD-tDCS dose and increase even more after personalized dose-controlled multifocal network-targeted HD-tDCS.
Description
This project is the first of two projects. The second project will be registered as a separate project in the future and enroll participants from this project.
Eligibility
- Age range
- 65–85 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Participants should be in good health with normal or corrected-to-normal visual acuity * Right handed * No history of neurological disorder * English speaker * Able to provide written consent prior to admission Exclusion Criteria: * Left-handed * Participants are pregnant, suspect pregnancy or are attempting to become pregnant * Have a pacemaker, intracardiac lines or any other medically implanted device or medicine pump * Have cochlear hearing implants * Taking drugs known to influence neural receptors that facilitate neuroplasticity (see protocol) * Have non removabl…
Interventions
- DeviceStandard HD-tDCS intervention
Participants will have three sessions along with behavioral assessments.
- DeviceMultifocal network targeted HD-tDCS intervention
Participants will have three sessions along with behavioral assessments.
- DeviceFunctional Magnetic Resonance Imaging (fMRI)
Participants will have an MRI before or after having HD-tDCS intervention.
Location
- University of MichiganAnn Arbor, Michigan