ISCHEMIA-LVD: International Study of Comparative Health Effectiveness With Medical and Invasive Approaches-Left Ventricular Dysfunction Trial
NYU Langone Health
Summary
The ISCHEMIA-HF trial will randomize participants with multivessel coronary artery disease (CAD) with ejection fraction (EF) ≤40% in a 1:2:2 fashion to guideline-directed medical therapy (GDMT):coronary artery bypass grafting (CABG):percutaneous coronary intervention (PCI).
Eligibility
- Age range
- 55+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Left ventricular ejection fraction (LVEF) ≤ 40% within prior 6 months (any local measurement, made within the past 6 months using echocardiography, multigated acquisition (MUGA), computed tomography (CT) scanning, magnetic resonance imaging (MRI), or ventricular angiography is acceptable, provided no subsequent measurement above 40%) * Participants with multivessel CAD (defined as severe 3 vessel disease or 2 vessel disease including left anterior descending (LAD) artery disease) on coronary CT angiography (CCTA) or invasive coronary angiography * CAD amenable to either…
Interventions
- ProcedureGuideline-directed medical therapy (GDMT)
Participants receive guideline-directed medical therapy (GDMT).
- ProcedureCoronary artery bypass grafting (CABG)
Participants receive coronary artery bypass grafting (CABG).
- ProcedurePercutaneous coronary intervention (PCI).
Participants receive percutaneous coronary intervention (PCI).
Locations (6)
- NYU Langone HealthNew York, New York
- International Study SiteInternational Study Site
- International Study SiteInternational Study Site
- International Study SiteInternational Study Site
- International Study SiteInternational Study Site
- International Study SiteInternational Study Site