University of Missouri-Columbia
The purpose of the research study is to better understand how beta-cells (cells in the pancreas that make insulin and help regulate blood sugar) respond to growth hormone in people with a family history of type 2 diabetes at the University of Missouri. Our aim is to advance understanding of how growth hormone affects beta-cells and risk factors for developing type 2 diabetes.
Inclusion Criteria: * 18 to 59 years old * body mass index ≥30.0 kg/m2 and \<45.0 kg/m2 Additional, group-specific inclusion criteria: * Family history of type 2 diabetes: first degree relative with type 2 diabetes * Control group: no family history of type 2 diabetes Exclusion Criteria: * Pregnant, planning to become pregnant during the study, or breastfeeding * Current diagnosis or history of type 1 or type 2 diabetes * Use of medications that can impact the study outcomes (e.g., GLP-1 receptor agonists) * History of bariatric surgery * Known, uncontrolled hypothyroidism * History of in…
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