Prospective, Double-Blinded, Randomized Study of Topical Almond Oil and Tretinoin on Facial Wrinkles
Integrative Skin Science and Research
Summary
Investigate the topical use of almond oil, almond oil augmented with 0.5% vitamin E, 0.025% tretinoin oil augmented with castor oil on the appearance of facial fine lines and wrinkles, pigmentation, hydration, trans-epidermal water loss, and sebum excretion rate.
Description
The natural cosmetic market is a multi-billion dollar industry. Nutraceuticals and food-based cosmetics are a growing trend within dermatology. Almonds are a rich dietary source of a range of fatty acids, phytochemical polyphenols, and antioxidants. Our previous study was a double blinded study that compared almond consumption interventions to a calorie matched intervention over 16 weeks. The study determined that that there was a statistically significant 8.41% improvement in wrinkle severity in the women that received almond supplementation. This proposal aims to now understand how the topic…
Eligibility
- Age range
- 18+ years
- Sex
- Female
- Healthy volunteers
- Yes
Inclusion Criteria: * Post-menopausal women of Fitzpatrick skin types 1, 2, and 3 * Individuals with facial fine lines and wrinkles Exclusion Criteria: * Individuals who are pregnant or breastfeeding * Prisoners * Adults unable to consent * Those with a nut allergy or tocopherol allergy * Current smokers, those that have smoked within the past year, and former smokers with greater than a 10-pack- year history of smoking * Those with an autoimmune photosensitive condition or a known genetic condition with a deficiency in collagen production (such as Ehlers-Danlos syndromes) * Those who have…
Interventions
- OtherTopical Product: Almond Oil
1-2 Drops of randomized topical product will be applied on entire face nightly.
- OtherTopical Product: Almond oil augmented with 0.5% Vitamin E
1-2 Drops of randomized topical product will be applied on entire face nightly.
- OtherTopical Product: 0.025% Tretinoin oil augmented with castor oil
1-2 Drops of randomized topical product will be applied on entire face nightly.
Location
- Integrative Research InstituteSacramento, California