Trial of Dexamethasone vs Placebo as an Adjunctive Therapy to Hyperbaric Oxygen Treatment HBO in Patients With Acute Carbon Monoxide Poisoning
University of Nebraska
Summary
Hyperbaric Oxygen Therapy (HBO) is routine treatment of carbon monoxide (CO) poisoning to prevent delayed neurological sequelae. This study looking to see if neurologic outcomes are improved with the addition of dexamethasone. CO poisoning can initiate a free radical mediated process that can instigate a demyelinating process resulting in long term neurological sequelae in some, but not all patients. In other demyelinating disorders, steroids are a part of first line treatment. HBO is already used for acute CO poisoning, so this pilot study will try to ascertain if the addition of steroids in concert with each hyperbaric oxygen session will yield improved outcomes.
Description
Hyperbaric Oxygen Therapy (HBO) is routine treatment of carbon monoxide (CO) poisoning to prevent delayed neurological sequelae. This study looking to see if neurologic outcomes are improved with the addition of dexamethasone. CO poisoning can initiate a free radical mediated process that can instigate a demyelinating process resulting in long term neurological sequelae in some, but not all patients. In other demyelinating disorders, steroids are a part of first line treatment. HBO is already used for acute CO poisoning, so this pilot study will try to ascertain if the addition of steroids in…
Eligibility
- Age range
- 19+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Acute CO poisoning, intentional or non-intentional exposure, receiving HBO treatment during hospitalization * Age \>18 years * Nebraska Medicine admission Exclusion Criteria: * Mechanical ventilation * No hospital admission or admission to hospital Critical Care Medicine Service * Allergy to dexamethasone * Pre-Existing neurological condition confounding outcome determination
Interventions
- Drugsaline placebo
IV saline bolus
- DrugDexamethasone
10mg IV Dexamethasone
Location
- Nebraska Medicine, Hyperbaric Medicine Program, Clarkson TowerOmaha, Nebraska