A Phase I/II Study of Cardiac Radioablation for Refractory Ventricular Tachycardia
Corewell Health East
Summary
The goal of this interventional study is to determine the minimum dose necessary for successful cardiac radioablation of refractory ventricular tachycardia (VT) and to study the utility of target volume definition using Delayed Enhancement Cardiac MRI (DE-CMR) .
Description
This voluntary study is designed to learn what is the minimum dose of radiation therapy (RT) needed to successfully reduce the incidence of refractory ventricular tachycardia (VT) by half. Additionally, the study will examine the utility of target volume definition using Delayed Enhancement Cardiac MRI (DE-CMR). Radiation therapy, given in a highly focused single dose to a portion of the heart, by a non-invasive method, has been found to change the electrical conduction of the heart. This will be done with the goal of reducing the number of episodes of VT in people where invasive thermal (heat…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Participants must be 18 years or older. * Automatic implanted cardiac defibrillator present. * VT is monomorphic with at least two episodes of VT within an eight week (56 day) period as recorded by an AICD or heart failure related to VT or VT storm. * Ejection fraction ≥20%. * At least one previous cardiac ablation for VT. * VT refractory despite antiarrhythmic medications. * Likely to live for 12 months in the absence of VT. * AICD in a position in the chest RT to be given without direct radiation. * Woman of reproductive age must ensure that she won't become pregnant o…
Interventions
- RadiationStereotactic Body Radiation Therapy (SBRT)
Stereotactic body radiation therapy, which delivers precise, high-dose radiation non-invasively to generate thermal scarring to myocardial targets causing VT
Location
- Corewell Health William Beaumont University HospitalRoyal Oak, Michigan