Assessments of Adipogenesis, Lipid Turnover and Cellular Composition in Adipose Tissue in Response to Endurance Exercise

Summary

The purpose of this research study is to study the effects of endurance exercise training on adipose (fat) tissue quality and insulin sensitivity in men and women.

Eligibility

Age range

18–45 years

Sex

All

Healthy volunteers

Yes

Interventions

• Procedure
  Muscle Biopsy

  This procedure is used to sample muscle cells from the leg Vastus Lateralis (thigh) muscle.

• Procedure
  Adipose Biopsy

  This procedure is used to sample fat tissue from the abdomen (belly).

• Other
  Glucose Clamp

  In this test, we will measure the effect of insulin by giving you insulin and glucose (sugar) intravenously through an IV line in your arm.

• Other
  Accelerometer

  The tri-axial accelerometer measure activity and uses those values to estimate the number of calories burned based on your height, weight, age, and gender. The monitor also evaluates physical effort and the body's response to different activities.

• Other
  Endurance Exercise

  Visit the study site 3 times a week to engage in endurance exercise training for approximately 12 weeks. Each session will last approximately 75 minutes, and exercise group can choose to use either a stationary bike or a treadmill to complete the training.

• Other

Locations (2)