The Role of Brain-Bone Marrow-Gut Interaction Following Major Trauma
University of Florida
Summary
Traumatic injury followed by critical illness provokes pathophysiologic changes in the bone marrow and the gut that contribute to persistent anemia and changes in the microbiome which significantly impact long-term recovery. This project will define the interactions between the stress, chronic inflammation, bone marrow dysfunction, and an altered microbiome which will provide a strong foundation for future clinical interventions to help improve outcomes following severe trauma.
Description
Trauma remains the leading cause of death among people younger than 46 years of age and is the leading cause of years of potential life lost among those younger than 65. With more lives saved, trauma morbidity has increased, which has consequently revealed a lack of understanding of the impact of trauma survivorship on the patients' quality of life and long-term recovery. Severe injury when followed by chronic critical illness leads to persistent anemia, and the use of blood transfusions is associated with a linear increase in infectious complications. These conditions are due to prolonged bon…
Eligibility
- Age range
- 18–100 years
- Sex
- All
- Healthy volunteers
- No
Severe Trauma Cohort Inclusion Criteria: 1. All adults (age ≥18). 2. Blunt trauma with an injury severity score \> 15 and a long bone or pelvic fracture requiring open reduction internal fixation or intramedullary fixation 3. Blunt trauma patients with shock, defined by either a systolic BP (SBP) \<90 mm Hg or base deficit (BD) ≥5 meq or lactate ≥ 2 mmol/L or active red blood cell or whole blood transfusion within 6h or arrival Exclusion Criteria: 1. Patients not expected to survive greater than 48 hours 2. Prisoners 3. Pregnancy 4. Previous bone marrow transplantation 5. Patients receivin…
Interventions
- OtherData and tissue collection
Collection of bone marrow, blood, feces, medical record data, and patient response surveys.
Locations (3)
- UF Academic Research BuildingGainesville, Florida
- UF Health at Shands HospitalGainesville, Florida
- UF Laboratory of Inflammation Biology and Surgical Science and Shands Hospital at UFGainesville, Florida