BCCMA: Recovery of Aged Muscle After Disuse Atrophy (REMEDY): Exercise and Monitoring With Post-Hospitalization Muscle Atrophy to Sustain Intrinsic Capacity and Strength (EMPHASIS)
VA Office of Research and Development
Summary
The aging Veteran population has more frequent inpatient hospitalization than non-Veterans. In addition, older Veterans have an inability to fully recover muscle mass and function after hospital-acquired weakness. The problem of hospital-acquired weakness is greatly increased in at-risk Veteran populations such as those with chronic kidney disease (CKD). The purpose of this collaborative study involving Denver and Baltimore VAMC sites is to improve health through the detection and rehabilitation management of hospital-acquired weakness in those with CKD. The study goals include identifying and monitoring the optimal muscle assessment sites in clinical settings, examining how muscle health impacts length of hospital stay and physical resilience, and determining how home-based and supervised exercise comparatively addresses post-hospitalization physical resilience using performance tests and Veteran feedback.
Description
This condition, known as disuse muscle atrophy, poses a substantial challenge to the health and well-being of individuals, particular those hospitalized. To tackle this problem , the project focuses on a specific group of individuals particularly vulnerable to this issues: Veterans with chronic kidney disease (CKD). This disease affects a substantial population of over 500,000 Veterans, leading to a progressive decline in mobility, unfavorable changes in lean body mass, and heightened hospitalization rates. To comprehensively address this concern, the project indents to develop and implement a…
Eligibility
- Age range
- 55+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Age \> 55 years * Diagnosis of stage 3-4 CKD or an eGFR of \<45 mL/min/1.73m2 Exclusion Criteria: * Cardiovascular risk: Poorly controlled hypertension (\>160/100) * Coronary event in past 6 months * Class III or IV CHF * symptomatic angina at rest or during exercise * Syncope in past year, without known resolution of cause * COPD requiring home oxygen * Contraindications to resistance training, including history of intracranial or retinal bleeding; Diabetes with active proliferative retinopathy * History of significant spinal osteoarthritis or spinal stenosis…
Interventions
- OtherExercise
The participants will exercise 2 days a week for 16 weeks. The exercises will include 4 movements: squats, shoulder press, seated row, and bicep curl focusing on internal load and contraction velocity.
Locations (2)
- Rocky Mountain Regional VA Medical Center, Aurora, COAurora, Colorado
- Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MDBaltimore, Maryland