Effect of Cannabinoids on Tobacco Product Demand and Pharmacodynamics: Cigarette Use
Johns Hopkins University
Summary
The purpose of this study is to determine the impact of tetrahydrocannabinol (THC) administration on motivational, subjective, and physiological effects of cigarettes. The study's goals are to test demand for cigarettes, tobacco craving, affect, heart rate, blood pressure, expired breath carbon monoxide, and cognitive performance. Researchers will compare multiple doses of THC and a placebo in participants who smoke cigarettes and either smoke or vape THC in the laboratory.
Description
A full-factorial laboratory study will be conducted to determine the impact of acute THC administration on the dose-related motivational, subjective, and physiological effects of combustible cigarettes. This study will employ a double-blind, placebo-controlled, within-subjects crossover design to examine the dose-effects of THC on combustible tobacco use. The study will use multiple active doses of THC and placebo (0, 5, and 30 mg; corresponding to 0, 1, and 6 standard THC unit doses). Participants will be randomized to either smoked or vaporized THC administration using a between-subjects app…
Eligibility
- Age range
- 21+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: 1. Healthy non-treatment seeking adults aged 21 or older 2. Report daily use of combustible tobacco cigarettes 3. Biological confirmation of cigarette use: have an expired carbon monoxide (CO) level of more than 5 ppm and a positive urine cotinine test at screening 4. Report current use of cannabis (at least 1 occasion per week) 5. Have experience with the inhalation route of administration for cannabis 6. Biological confirmation of cannabis use: have a positive urinary THC drug test at screening. 7. For women of children bearing potential and men with female partners of c…
Interventions
- DrugTHC 30mg
High dose of THC (30 mg)
- DrugTHC 5mg
Low dose of THC (5 mg)
- DrugTHC 0mg
Placebo dose of THC (0 mg)
- DrugCigarette Full Nicotine
Full nicotine cigarette
- DrugCigarette Reduced Nicotine
Reduced nicotine cigarette
Location
- Johns Hopkins University Behavioral Pharmacology Research UnitBaltimore, Maryland