Johns Hopkins University
The purpose of this study is to determine the impact of tetrahydrocannabinol (THC) administration on motivational, subjective, and physiological effects of cigarettes. The study's goals are to test demand for cigarettes, tobacco craving, affect, heart rate, blood pressure, expired breath carbon monoxide, and cognitive performance. Researchers will compare multiple doses of THC and a placebo in participants who smoke cigarettes and either smoke or vape THC in the laboratory.
A full-factorial laboratory study will be conducted to determine the impact of acute THC administration on the dose-related motivational, subjective, and physiological effects of combustible cigarettes. This study will employ a double-blind, placebo-controlled, within-subjects crossover design to examine the dose-effects of THC on combustible tobacco use. The study will use multiple active doses of THC and placebo (0, 5, and 30 mg; corresponding to 0, 1, and 6 standard THC unit doses). Participants will be randomized to either smoked or vaporized THC administration using a between-subjects app…
Inclusion Criteria: 1. Healthy non-treatment seeking adults aged 21 or older 2. Report daily use of combustible tobacco cigarettes 3. Biological confirmation of cigarette use: have an expired carbon monoxide (CO) level of more than 5 ppm and a positive urine cotinine test at screening 4. Report current use of cannabis (at least 1 occasion per week) 5. Have experience with the inhalation route of administration for cannabis 6. Biological confirmation of cannabis use: have a positive urinary THC drug test at screening. 7. For women of children bearing potential and men with female partners of c…
High dose of THC (30 mg)
Low dose of THC (5 mg)
Placebo dose of THC (0 mg)
Full nicotine cigarette
Reduced nicotine cigarette
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