Effect of Cannabinoids on Tobacco Product Demand and Pharmacodynamics: Electronic Cigarette Use
Johns Hopkins University
Summary
The purpose of this study is to determine the impact of tetrahydrocannabinol (THC) administration on motivational, subjective, and physiological effects of electronic cigarettes. The study's goals are to test demand for e-cigarettes, tobacco craving, affect, heart rate, blood pressure, expired breath carbon monoxide, and cognitive performance. Researchers will compare multiple doses of THC and a placebo in participants who smoke e-cigarettes and either smoke or vape THC in the laboratory.
Description
A full-factorial laboratory study will be conducted to determine the impact of acute THC administration on the dose-related motivational, subjective, and physiological effects of electronic cigarettes. This study will employ a double-blind, placebo-controlled, within-subjects crossover design to examine the dose-effects of THC on e-cigarette use. The study will use multiple active doses of THC and placebo (0, 5, and 30 mg; corresponding to 0, 1, and 6 standard THC unit doses). Participants will be randomized to either smoked or vaporized THC administration using a between-subjects approach to…
Eligibility
- Age range
- 21+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion criteria: 1. Healthy non-treatment seeking adults aged 21 or older 2. Report daily use of e-cigarettes 3. Biological confirmation of e-cigarette use: have a positive urine cotinine test at screening 4. Report current use of cannabis (at least 1 occasion per week) 5. Have experience with the inhalation route of administration for cannabis 6. Biological confirmation of cannabis use: have a positive urinary THC drug test at screening. 7. For women of children bearing potential and men with female partners of child-bearing potential, must be willing to use an effective form of contracep…
Interventions
- DrugTHC High Dose
Low dose of THC (30 mg)
- DrugTHC Low Dose
Low dose of THC (5 mg)
- DrugTHC 0mg
Placebo dose of THC (0 mg)
- DrugE-Cigarette Full Nicotine
E-Cigarette with Nicotine
- DrugE-Cigarette Placebo Nicotine
E-Cigarette with No Nicotine
Location
- Johns Hopkins University Behavioral Pharmacology Research UnitBaltimore, Maryland