Longitudinal Effects of E-cigarette Use on Cardiovascular and Pulmonary Health
University of Wisconsin, Madison
Summary
Electronic nicotine delivery systems (ENDS) are used by millions of Americans, however their long-term health effects are unknown. This research proposal will quantify the effects of long-term ENDS use on validated and novel biomarkers of cardiovascular and pulmonary disease and how they are influenced by use heaviness, age, body weight, and co-use of other products. This study will produce the most informative evidence to date on how long-term ENDS use affects cardiovascular and pulmonary health.
Description
Electronic nicotine delivery systems (ENDS) are used by millions of Americans, however, their long-term health effects are unknown. Although ENDS use delivers far lower levels of carcinogens than tobacco smoking, very little is known about whether ENDS use affects the risks of developing cardiovascular (CV) or pulmonary diseases, two of the most highly prevalent causes of morbidity and mortality in the United States. This research proposal will quantify the effects of long-term ENDS use on validated and novel biomarkers of CV and pulmonary disease and how they are influenced by use heaviness,…
Eligibility
- Age range
- 21+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * greater than or equal to 21 years of age * has vaped a nicotine e-cigarette product at least 2 days/week for most weeks for greater than or equal to 12 months * plans to remain in catchment area for greater than or equal to 3 years * smoked 5 or fewer tobacco cigarettes in the past 6 months * no serious CV, pulmonary, or other medical problems * not currently pregnant * no plans to stop vaping Exclusion Criteria: * serious CV, pulmonary, or other medical problems (e.g., moderate or severe aortic stenosis, class III or IV heart failure, blood pressure greater than or eq…
Interventions
- OtherHealth Assessments
Participants will complete the blood tests, questionnaires, cardiovascular tests, and pulmonary test at visits 1, 2, and 4. Non-Contrast Chest CT and cardiopulmonary treadmill (VO2 max) stress tests will occur at visits 1 and 4. Visit 3 will not include cardiovascular and pulmonary tests.
Location
- UW Center for Tobacco Research and InterventionMadison, Wisconsin