Point-of-Care Ophthalmic Diagnostic Imaging of Retinopathy of Prematurity
Vanderbilt University Medical Center
Summary
The goal of this proposal is to develop novel HH-SECTR technology for visualizing and quantifying diagnostic disease features in prematurely born infant retinopathy of prematurity (ROP) patients that lead to more informed clinical decision making. Providing depth-resolved vascular information has not been adequately investigated for its diagnostic potential. Furthermore, we seek to identify disease features not currently accessible by standard examination methods to better inform clinical decisions.
Description
Imaging studies using HH-SECTR will be performed to assess and quantify structural and vascular disease features associated with ROP. Weekly HH-SECTR imaging will be performed concurrently with standard-of-care weekly ROP screening. No additional treatments will be given to study patients to benefit HH-SECTR imaging (e.g., sedation, dilation, etc.). Study patients will primarily be imaged in the NICU, but may also be performed under sedation or anesthesia in the operating room concurrent with standard-of-care exams. Because this study will evaluate diagnostic features prognostic of ROP progres…
Eligibility
- Age range
- 0–0 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Preterm male and female infants born at 24-34 weeks gestational age and weighing \<1500g at birth Exclusion Criteria: * Infants surgically treated for ROP * Infants with significant health concern that would preclude noninvasive retinal imaging as noted by the primary inpatient team
Location
- Vanderbilt University Medical CenterNashville, Tennessee