Examining the Effects of Cytisinicline on Neural Substrates of Cigarette Cue-Reactivity
University of California, Los Angeles
Summary
This study will randomize 64 non-treatment seeking individuals who smoke cigarettes daily in a double-blind, placebo-controlled laboratory study testing the effects of cytisinicline on the neural substrates of cigarette cue reactivity.
Description
The objective of this study is to examine the effects of cytisinicline on neural substrates of cigarette cue-reactivity. We will randomize 64 adults who smoke cigarettes daily (N=32 cytisinicline, N=32 placebo; 50% female) into a double-blind, placebo-controlled laboratory study of cytisinicline. Specifically, participants will complete a 2- to 3-week outpatient protocol that includes taking cytisinicline (3 mg, 3 times daily) or matched placebo (0 mg, 3 times daily) and completing a brief daily diary assessment of cigarette use and craving. Following 2- to 3-weeks of cytisinicline (or placebo…
Eligibility
- Age range
- 18–65 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1. be between the ages of 18 and 65 and provide informed consent; 2. smoke 5 or more combustible cigarettes per day; 3. not seeking treatment for smoking; Exclusion Criteria: 1. current use of other smoking cessation aid (bupropion, varenicline, nortriptyline, NRT); 2. more than 3 months of smoking abstinence in past year; 3. use of non-cigarette tobacco product (pipe tobacco, cigars, smokeless tobacco, hookah) or electronic cigarettes more than 5 times in the 28-days prior to enrollment; 4. current use of psychoactive drug (excluding cannabis), as determined by urine to…
Interventions
- DrugCytisinicline
Targets α4β2 nicotinic acetylcholine receptors
- DrugPlacebo Oral Capsule
Matched to active drug, cytisinicline
Location
- University of California Los AngelesLos Angeles, California