Effectiveness of Azithromycin in Eradicating Nasopharyngeal Carriage of N. Meningitidis
Emory University
Summary
The purpose of this study is to determine the effectiveness of azithromycin in the eradication of nasopharyngeal carriage of N. meningitidis
Description
Azithromycin belongs to the class of antimicrobials known as macrolides. They are approved for the treatment of a wide variety of infections, including community-acquired respiratory tract infections and sexually transmitted infections caused by different bacteria. Their mechanism of action is dependent on bacterial ribosomal binding, leading to inhibition of bacterial protein synthesis. Azithromycin has a broad spectrum of activity to include Gram-positive and Gram-negative organisms, as well as atypical and mycobacterial organisms. A single oral dose of 500mg of azithromycin has been shown…
Eligibility
- Age range
- 18–25 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Able to provide their own informed consent and understand study procedures * Undergraduate and graduate students attending Emory University affiliated campuses who reside in university affiliated housing (for undergraduate/graduate) or in off-campus housing (undergraduates). Exclusion Criteria: * University faculty and staff * Currently pregnant or breast feeding * History of immediate or moderate-to-severe allergic reactions to azithromycin * Individuals who have taken systemic antibiotics for any reason in the 30 days prior to enrollment * Individuals with any sympto…
Interventions
- DrugAzithromycin
A standard dose of azithromycin (500 mg) will be delivered by oral route.
Location
- Hope Clinic of the Emory Vaccine CenterDecatur, Georgia