AMD and Validating Rod-Meditated Dark Adaptation With Everyday Task Performance
Duke University
Summary
The goal is to conduct a cross-sectional, single timepoint study on older adults with early and intermediate AMD, and with subretinal drusenoid deposits (SDD), and those in normal health, establishing an association between dark adaptation and reading performance under dim illumination, both which depend on rod photoreceptors.
Description
The investigators propose two sites for the study, Duke University and UAB. Each site will enroll 100 participants as indicated in the table above, per the AREDS 9-step AMD classification system, with 200 participants in the sample. Because the variance of rod-mediated dark adaptation in AMD patients increases with increasing disease severity, the investigators will implement a larger sample size for intermediate AMD and a smaller sample for patients in normal macular health. The investigators will collect demographic characteristics (age, race/ethnicity, gender), ocular medical history from…
Eligibility
- Age range
- 50–89 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Capable and willing to provide consent * Has been diagnosed with early, intermediate dry age-related macular degeneration or geographic atrophy or has a healthy macular for controls * At least 50 years of age Exclusion Criteria: * Unable or unwilling to give consent or unable to read consent since the study involves testing which requires reading * Under 50 years of age * Presence of dense cataracts in the study eye (s) that can affect visual function tests * Presence of glaucoma requiring treatment during the study and/or visual field defects * Previous retinal laser…
Interventions
- Diagnostic TestStreetlab VR
Streetlab VR is a virtual reality headset that is warn to simulate walking through a maze at different light levels.
Location
- Duke Eye CenterDurham, North Carolina