Prandial Metabolic Phenotyping in Sarcopenic Older Adults Comparing Plant Based and Whey Based Protein
Texas A&M University
Summary
The researchers overall objective is to determine whether plant and animal protein based proteins affect the anabolic responses across aging populations differently due to specific changes in the essential amino acids (EAA) and non-essential amino acids (NEAA) kinetic responses. The researchers central hypothesis is that a high EAA to NEAA ratio in a protein meal is related to higher anabolic response to the meal. The researchers also hypothesize that the type of NEAA in a protein meal also affects the anabolic capacity of the meal. The researchers rationale is that finding the amino acid composition of a meal that will maximally induce protein anabolism will guide novel nutritional approaches to prevent and treat sarcopenia, thereby reducing both overall economic burden and improving individual patient outcomes.
Description
The study will be conducted in sarcopenic and non-sarcopenic older adults, stratified into different age categories. A sip feeding model will be used as it is a good model to establish the anabolic capacity of meals. The researchers hypothesize that plant-based protein induces less protein anabolism, due to lower production of EAA and higher production of non-essential amino acids (NEAA) as compared to dairy protein. The NEAA kinetics will be different between the plant proteins as soy protein has relatively high levels of the NEAA arginine and Pea protein of aspartate/glutamate. The researche…
Eligibility
- Age range
- 50–95 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Age 50-95 years old * Diagnosis of Chronic Obstructive Pulmonary Disease (COPD); COPD group only * Stable body-weight (±5%) for the past 3 months * Ability to walk, sit down, and stand up (independently or with walking assistance device) * Willingness to lay supine in bed for up to 6 hours * Willingness and ability to comply with the protocol Exclusion Criteria: * Established diagnosis and active treatment of chronic disease: Insulin dependent diabetes mellitus, active malignancy, heart disease, kidney disease, liver disease, HIV/AIDS, Asthma (moderate to severe), Hep…
Interventions
- Dietary SupplementWhey Protein Isolate 90%
Commercially available animal based protein powders
- Dietary SupplementSoy Protein Isolate (90% Protein)
Commercially available plant based protein powders
- Dietary SupplementOrganic Pea Protein Isolate
Commercially available plant based protein powders
- Dietary SupplementPlacebo (Water)
Normal drinking water
Location
- Texas A&M University - CTRALCollege Station, Texas