Addiction Potential of Very Low Nicotine Filtered Little Cigars
Ohio State University Comprehensive Cancer Center
Summary
The goal of this clinical trial is to learn how reducing the nicotine content in filtered little cigars can affect the the use of these cigars and lung health in current adult filtered little cigar users. The main question\[s\] it aims to answer are: Are puffing behaviors, appeal/satisfaction, craving suppression, pharmacokinetic effects, and demand similar between the regular cigars smoked by participants, normal nicotine study cigars and very low nicotine study cigars? Are health effects and toxicant exposure similar between the regular cigars smoked by participants, normal nicotine study cigars and very low nicotine study cigars? Participants will attend three study visits at OSU. Each visit would last up to 4 hours. During visits, they will * fill several surveys * provide blood samples * perform breathing tests * complete smoking sessions using either their own cigars or the study cigars.
Eligibility
- Age range
- 21–75 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Smokers: 1) self-reported regular current filtered little cigars, cigarillos, little cigars, or small cigars use for the past 3 months; regular use will be defined as \>=8 cigars smoked per month based on data showing median cigarillo use is 7.5 times per month and median FLC use is 14 times per month 59. We will attempt to bring in heavier users if feasible during recruitment; or 2) Cigarette smokers (\>=8d/month for at least 3 months) with either (i) co-use of filtered little cigars, cigarillos, little cigars, or small cigars (at least once in their lifetime) or (ii) a…
Interventions
- DrugReduced Nicotine Content Cigars
Participants will smoke a very low nicotine content filtered little cigar containing 0.50mg nicotine per gram of tobacco
- DrugNormal nicotine content cigar
Participants will smoke a normal nicotine content filtered little cigar containing 5.17mg nicotine per gram of tobacco
- DrugUsual brand cigar
Participants will smoke their usual brand filtered little cigar
Location
- The Ohio State UniversityColumbus, Ohio