Addiction Potential of Very Low Nicotine Filtered Little Cigars

Summary

The goal of this clinical trial is to learn how reducing the nicotine content in filtered little cigars can affect the the use of these cigars and lung health in current adult filtered little cigar users. The main question\[s\] it aims to answer are: Are puffing behaviors, appeal/satisfaction, craving suppression, pharmacokinetic effects, and demand similar between the regular cigars smoked by participants, normal nicotine study cigars and very low nicotine study cigars? Are health effects and toxicant exposure similar between the regular cigars smoked by participants, normal nicotine study cigars and very low nicotine study cigars? Participants will attend three study visits at OSU. Each visit would last up to 4 hours. During visits, they will * fill several surveys * provide blood samples * perform breathing tests * complete smoking sessions using either their own cigars or the study cigars.

Eligibility

Age range

21–75 years

Sex

All

Healthy volunteers

Yes

Interventions

• Drug
  Reduced Nicotine Content Cigars

  Participants will smoke a very low nicotine content filtered little cigar containing 0.50mg nicotine per gram of tobacco

• Drug
  Normal nicotine content cigar

  Participants will smoke a normal nicotine content filtered little cigar containing 5.17mg nicotine per gram of tobacco

• Drug
  Usual brand cigar

  Participants will smoke their usual brand filtered little cigar

Location