In Vitro Maturation of Human Eggs
Colorado Center for Reproductive Medicine
Summary
CCRM Fertility, a global pioneer in fertility treatment, research and science, is seeking participants for a new study on in vitro maturation (IVM). IVM requires less hormones to stimulate the ovaries than IVF, making it more affordable than IVF with fewer side effects. Participants that qualify for the study will receive a free cycle of IVM treatment at CCRM Fertility and including a new patient consultation, fertility testing, preimplantation genetic testing for aneuploidies (PGT-A), anesthesia and some medication
Description
Patients will undergo a complete IVF workup to qualify for study. Once passing their baseline appointment patients will undergo a three day low dose stimulation followed by egg retrieval 18-22 hours post last medication dosage. Immature oocytes will be retrieved from the ovaries via ultrasound guided TV aspiration and matured overnight in the laboratory. Mature oocytes will be fertilized via ICSI the following day and cultured to the blastocyst stage. Biopsy of the first 14 blastocysts are included with this package, patients have the option biopsy additional embryos if available. Biopsies wil…
Eligibility
- Age range
- Up to 38 years
- Sex
- Female
- Healthy volunteers
- No
Inclusion Criteria: * Infertile women diagnosed with PCOS or polycystic ovaries, or infertile women with good ovarian reserve * Antral follicle count (AFC) greater than 24 * AMH greater than 3.5 ng/ml * Body Mass Index less than 35 * Accept to have embryos biopsied for PGT * Intend to perform embryo transfer within 4 months after completing the IVM cycle * Paternal (or donor) age \<45, ejaculated sperm collection only (partner frozen and donor sperm acceptable), sperm morphology (strict criteria) \>1%, motility \> 20% and sperm count \> 10 million per ml (so samples can be prepare…
Interventions
- OtherIVM
Immature oocytes will be retrieved from small ovarian follicles and matured overnight in the laboratory prior to undergoing fertilization and embryo culture.
Location
- Colorado Center for Reproductive MedicineLone Tree, Colorado