Evaluating the Role of the Microbiome in Antidepressant Treatment in Adolescents.
University of California, San Diego
Summary
The goal of this observational study is to learn about the role of the human gut microbiome in antidepressant treatment response in adolescents with Major Depressive Disorder (MDD). Specifically, the study aims to collect microbiota samples of adolescents treated with fluoxetine, over the span of 8-weeks, to: * determine the influence of the microbiome on the efficacy of fluoxetine to treat adolescent depression. * test whether the gut microbiome from different timepoints can predict ultimate success of fluoxetine * investigate the interaction of gut microbiome composition and pharmacogenetic metabolizer status on steady-state plasma concentrations of fluoxetine. Depression symptom severity will be evaluated upon enrollment and 6-weeks into antidepressant treatment.
Description
For this project the investigators are interested in changes in the gut microbiome associated with adolescent depression and the influence of the microbiome on the efficacy of fluoxetine to treat adolescent depression. It is hypothesized that the composition of the human gut microbiome alters the response to fluoxetine of adolescents with depression. This study aims to collect gut microbiota of adolescents being treated with antidepressants at several timepoints to (1) determine the efficacy of fluoxetine to treat depression, (2) test whether the gut microbiome from different timepoints can pr…
Eligibility
- Age range
- 13–17 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Subjects from all ethnic backgrounds will be eligible to participate. * Having clinically significant depressive symptoms based on a score \>40 on the Children's Depression Rating Scale-Revised * Prescribed more than 5mg of Fluoxetine (Prozac) * Has an identifiable legal guardian. Exclusion Criteria: * Has been taking a standing psychotropic medication in the past 6 months * Has been taking antibiotics or metformin during the past 6 months (known strong effects on gut microbiome) * Admitted to RCHSD CAPS post-overdose (potential strong effects on gut microbiome) * Curr…
Location
- Rady Children's Hospital San DiegoSan Diego, California