Vanderbilt University Medical Center
The goal of this work is to use advanced magnetic resonance imaging (MRI) methods to assess brain blood flow and vascular function in adults with moyamoya disease (MMD). MMD is a condition characterized by narrowing or obstruction of major arteries in the brain and people with MMD have a high risk of stroke. Study participants will be enrolled from Vanderbilt University Medical Center and Johns Hopkins Hospital and will undergo up to two MRI scans where measurements of cerebrovascular reserve are performed using inhaled room air mixed with 5% carbon dioxide. Scans will be performed before and after surgeries to treat MMD, all surgeries are clinically indicated and are not research procedures. To further understand how surgeries impact brain health, we will also perform neurological exams and cognitive testing at approximately the same time as the imaging scans. The overall goal is to incorporate advanced imaging and cognitive assessments to understand how surgeries improve brain health in these patients, and furthermore, to use this information to develop improved screening tools for stroke risk and decisions about surgery.
MMD is a condition with narrowing and blockage of major arteries in the brain and people with MMD have a high risk of stroke. Neurosurgical revascularization surgery is usually recommended to provide more blood flow to the brain and hopefully prevent further strokes. The primary goal of this study to improve the understanding of response to neurosurgical treatment and disease improvement or progression by using innovative magnetic resonance imaging (MRI) methods to assess brain blood flow and oxygen use in adults with idiopathic MMD before and after they have surgery. The study will recruit 1…
Inclusion Criteria: Moyamoya 1. Clinical diagnosis of moyamoya disease as defined by gold-standard catheter angiography and consensus adjudication of imaging and neurological findings 2. Age = 18-60 years 3. Participants for the surgical revascularization aims must be scheduled for clinically indicated indirect surgical revascularization of at least one hemisphere 4. Speak and read English Healthy controls 1. No major medical conditions 2. Age = 18-60 years 3. Speak and read English 4. Able to complete 2 study MRIs and all other study procedures Exclusion Criteria: -Both moyamoya and hea…
The study will utilize the MRI diagnostic reactivity test to evaluate cerebrovascular reactivity in patients with moyamoya and healthy controls. All participants (patients and controls) receive the same diagnostic scan, and there is no cross-over, factorial, or sequential nature to the study.