Preliminary Characterization of Commercial Kratom Extract Products
Johns Hopkins University
Summary
To understand the acute subjective, physiological, and cognitive effects of commercial kratom extract products among US adults who consume these products regularly, and to understand how these products are metabolized by the human body.
Description
Kratom products, made from the botanical Mitragyna speciosa, have proliferated in the United States since 2006 and now include a variety of brands and formulations. Kratom whole-leaf products and kratom leaf-derived extract products are the two major types of products within the marketplace. To date, most studies have examined kratom whole-leaf products, both in terms of self-report from consumers and in terms of two US-based, small lab-based pharmacokinetic/pharmacodynamic (PK/PD) studies. In order to follow-up on the investigators' prior work examining the acute effects of kratom in adults (…
Eligibility
- Age range
- 21+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * 1\) \>21 years old; * 2\) Experienced kratom extract product consumer of one of the leading US brands listed in the study protocol; * 3\) Reports a specific kratom extract product brand and specific dose amount (or range of typical dose amount) on the online screener; * 4\) English language proficient; * 5\) Willingness to provide requested samples of the kratom extract product currently being taken. Exclusion Criteria: * 1\) Reports any acute adverse or unexpected or otherwise sudden health event related to their typical kratom product dose that occurred within 30 day…
Locations (2)
- Johns Hopkins University Behavioral Pharmacology Research UnitBaltimore, Maryland
- Johns Hopkins UniversityBaltimore, Maryland