Evaluating the Impact of Intermittent Fasting in Combination With Checkpoint Inhibitors in Patients With Non-small Cell Lung Cancer
VA Office of Research and Development
Summary
The purpose of this study is to learn the effects of fasting on cancer cells while you get maintenance treatment.
Description
Cancer cells use an increased supply of glucose to make energy and do not have protection against fasting that normal cells do. Because of this, researchers would like to study how fasting may help immunotherapy target cancer cells. Initial studies suggest that fasting may decrease the side effects of immunotherapy and increase the chances of your cancer responding to the immunotherapy. Patient populations will have non-small cell lung cancer in which pembrolizumab have been recommended to treat the cancer as part of standard care
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * 18 years at the time of informed consent * Ability to provide written informed consent and HIPAA authorization. * Eastern cooperative group (ECOG) performance status of 0 to 2 * Newly diagnosed histologically or cytologically confirmed stage IV Non-Small Cell Lung Cancer (NSCLC). Patients with locally advanced NSCLC that are not candidates for definitive therapy but are candidates for trial are allowed per investigator discretion. * BMI 19 kg/m2 * Patients should be enrolled prior to starting standard of care immunotherapy for the treatment of stage IV NSCLC. Patients sh…
Interventions
- Dietary SupplementFMD
Plant-based diet program
- Combination ProductRegular Diet Plus FMD
Patients will eat a RD with the first 3 cycles, then receive 3 cycles of FMD as they continue cycles 4-6
Locations (4)
- VA Long Beach Healthcare System, Long Beach, CALong Beach, California
- Jesse Brown VA Medical Center, Chicago, ILChicago, Illinois
- Richard L. Roudebush VA Medical Center, Indianapolis, INIndianapolis, Indiana
- St. Louis VA Medical Center John Cochran Division, St. Louis, MOSt Louis, Missouri