The Acute Effects of an Endurance Exercise Bout the Gut Microbiome and Gut-derived Metabolome in Women's Distinct Fitness and Body Mass Indexes
George Washington University
Summary
This study aims to elucidate the differences in the gut microbiome functional activity and metabolome in adult premenopausal women with distinctive fitness levels and BMIs (with obesity, w/o obesity). The specific aims are as follows: * Aim 1: To examine the effects of acute aerobic exercise at 60-70% heart rate reserve (HRRmax) for 30 minutes bout on changes in the abundance of SCFA-producing bacteria and their functional downstream metabolic activity. * Aim 2: To examine the effects of acute aerobic exercise at 60-70% HRRmax 30-minute bout on changes in GM-released SCFA concentrations in stool and plasmatic metabolome.
Description
Participants who are eligible after completing the online questionnaire will be invited to three in-person visits: VISIT A (baseline visit) * Participants will receive oral and written information about the study and be allowed to ask questions. * Participants will sign the informed consent document. * Inclusion and exclusion criteria will be reviewed. * Demographic, health, and lifestyle data will be collected. * Collection of height and weight. * Body composition analysis via DXA scan * Strength test: isometric mid-thigh pull and hand-grip strength test. * Endurance test: A cardiovascular…
Eligibility
- Age range
- 21–40 years
- Sex
- Female
- Healthy volunteers
- Yes
Inclusion Criteria: * Biological sex: female * BMI 19 to 24.99 kg/m2 or BMI 30-40 kg/m2 * Exercisers: Exercise at least 4 times per week for 60 minutes (a total of 240 minutes per week) on a programmed exercise training either on endurance sports (e.g., running, cycling, triathlon), strength (e.g., powerlifting), or team sports (e.g., rugby, football, soccer) * Non-Exercisers: Sedentary individuals who have not reached the PA guidelines (150 minutes of moderate-intensity physical activity a week, 75 minutes of vigorous-intensity physical activity, or an equivalent combination of moderate and…
Interventions
- BehavioralAerobic Exercise
30-minute exercise bout in a cycle ergometer at 60 to 70% of the Heart Rate Reserve (HRR) and corresponding power (watts).
Location
- Milken Institute School of Public Health, The George Washington UniversityWashington D.C., District of Columbia