Defining Inflammatory Biomarkers of Cardiovascular Disease in Patients With Myelodysplastic Syndromes
University of Vermont
Summary
Why Is This Research Study Being Conducted? * The study wants to find out why people with a type of blood cancer called myelodysplastic syndromes (MDS) are more likely to have heart problems like heart disease and stroke. * Researchers also want to see if certain proteins related to inflammation in the body can help predict these heart issues in MDS patients. * By understanding this better, researchers hope to find new ways to detect and manage heart disease risks in people with MDS
Description
What Is Involved in The Study? * This study will follow patients with MDS over 6 months. * Participants will come to the hospital for the first visit. Participants will learn about the study, sign papers to join the study, and share some basic health information. Participants will also give a blood sample of 10 milliliters after not eating overnight. * After the first visit, participants will come back to the hospital once a week for 3 weeks to give more blood samples after fasting overnight. * The study team will call participants the day before each scheduled blood draw to remind you of you…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Age ≥18 years * Histologically confirmed diagnosis of MDS by bone marrow biopsy morphology, using the 2022 World Health Organization (WHO) classification for myeloid neoplasms * Eastern Cooperative Oncology Group (ECOG) performance status ≤3 * Expected survival of at least 6 months * Ability to provide consent Exclusion Criteria: * Cases meeting 2022 WHO criteria of MDS with excess blasts 2 as initial diagnosis * Hematopoietic stem cell transplantation expected within 6 months
Interventions
- OtherObservational
Blood will be collected from one cohort to identify potential blood biomarkers.
Location
- University of VermontBurlington, Vermont