Mayo Clinic
The purpose of this study is to determine the most efficient and safest dexamethasone dose given perioperatively during total knee arthroplasty that reduces postoperative option consumption and pain, improves postoperative nausea and vomiting, and minimizes postoperative complications
Perioperative multimodal analgesia and anesthesia regimens have become the standard of care in modern total joint arthroplasty. This has been driven in part by an emphasis on decreasing postoperative opiate use, a growing trend towards shorter inpatient hospital stays and outpatient TKAs, and motivation to improve patient satisfaction after TKA. Acute postoperative pain not only decreases patient satisfaction,1 but can also lead to associated complications including chronic opioid use,2 disrupted sleep,3 and impaired early mobilization, which can prolong recovery and increase the risk of medic…
Inclusion Criteria * Age \> 18 years * Primary total knee arthroplasty Exclusion Criteria * Age \< 18 year * Revision or unicompartmental knee arthroplasty * Corticosteroid use within 3 months prior to TKA * Inflammatory arthritis * Current systemic fungal infection * Renal or liver failure * Prior adverse reaction to corticosteroid * Primary TKA requiring hardware removal
Patients will receive dexamethasone administered intraoperatively at the time of anesthesia. The dose of dexamethasone will be 16mg intravenous (IV) if you do not have a prior diagnosis of diabetes mellitus, or 8mg IV if you do have a previous diagnosis of diabetes mellitus.
Patients will receive dexamethasone administered intraoperatively and on the morning of the first postoperative day. The dose of dexamethasone will be 16mg intravenous (IV) if you do not have a prior diagnosis of diabetes mellitus, or 8mg IV if you do have a previous diagnosis of diabetes mellitus. The medication will be intravenously administered while inpatient, and via oral route when discharged.
Patients will receive dexamethasone administered intraoperatively, the morning of the first postoperative day, and the morning of the second postoperative day. The dose of dexamethasone will be 16mg intravenous (IV) if you do not have a prior diagnosis of diabetes mellitus, or 8mg IV if you do have a previous diagnosis of diabetes mellitus. The medication will be intravenously administered while inpatient, and via oral route when discharged.
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