Medical University of South Carolina
Dementia is an ongoing and growing public health crisis in the US and worldwide. The purpose of this study is to examine a form of noninvasive brain stimulation called transcranial focused ultrasound (tFUS) to the hippocampus with the goal of improving memory.
Dementia is an ongoing and growing public health crisis in the US and worldwide. Currently, there are an estimated 6.2 million Americans living with Alzheimer's Disease (AD) the most common form of dementia accounting for roughly 75% of cases. With a growing aging population, this number is estimated to be 13.8 million in the US and 152.8 million people worldwide by 2050 with a 14% lifetime prevalence. It is difficult to treat AD, making it critical to intervene as early as possible. Mild neurocognitive disorder (mNCD) is an early stage of memory and cognitive ability loss that is more severe…
Inclusion Criteria for Healthy Older Adults * Age 50-85 * English as a first/primary language * Capacity to consent * No Diagnosis of mNCD or dementia Exclusion Criteria for Healthy Older Adults * Current substance use disorder, bipolar disorder, or schizophrenia spectrum or other psychotic diagnosis * Daily/weekly anticholinergic or sedative use. Stimulants may be used pending investigator review. Cholinesterase inhibitors, NMDA receptor antagonists, and antidepressants are allowed if on a stable regimen for 4 weeks prior to enrollment * History of significant or unstable conditions that m…
Using MRI-guided targeting, we will administer focused ultrasound to one of the 4 brain locations
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