Time-Efficient Inspiratory Muscle Strength Training for Reducing Sympathetic Activity and Improving Sleep in Midlife Women

Mayo Clinic

Summary

The purpose of this research is to understand how training the muscles used for breathing (inhalation) affects menopausal hot flashes, sympathetic nerve activity and sleep.

Eligibility

Age range: 45–60 years
Sex: Female
Healthy volunteers: Yes

Detailed criteria

Inclusion Criteria: * Females aged 45-60 with hot flashes. * Participants will be recruited from Rochester, MN and surrounding areas. * Non-smokers. * BMI \< 40kg/m\^2. * No history of cardiovascular disease, except for hypertension. Exclusion Criteria: * Detailed medical and social histories will be collected. To allow for ecological validity, participants will not be excluded for use of menopausal hormone therapy or medications affecting cardiovascular function so long as they have been on a consistent regimen for ≥3 months and during the study period. This approach to medications is cons…

Interventions

Behavioral
High-Resistance Inspiratory Muscle Strength Training
Performs inspiratory maneuvers at 55% maximal inspiratory pressure (PIMAX) during week 1, 65% PIMAX during week 2, and 75% PIMAX during weeks 3-6.
Behavioral
Low-Resistance Inspiratory Muscle Strength Training
Performs inspiratory maneuvers at 15% maximal inspiratory pressure (PIMAX) for all 6 weeks.
Device
POWERbreathe K3 device
Inspiratory muscle training device

Location

Mayo Clinic in Rochester
Rochester, Minnesota

Time-Efficient Inspiratory Muscle Strength Training for Reducing Sympathetic Activity and Improving Sleep in Midlife Women

Summary

Eligibility

Interventions

Location

Run this study?

Details

Conditions