The Low-Down on Methamphetamine Isomers: Prevalence and Pharmacology in Humans
University of Wisconsin, Madison
Summary
This study is being done to understand the metabolism and impairment profile of methamphetamine (meth). Meth exists as two chemical structures that are mirror images of each other: R-meth and S-meth. S-meth is a strong central nervous system stimulant and used to treat attention deficit disorder (ADD). R-meth is not a strong central nervous system stimulant and is available over-the-counter in nasal decongestant sprays.17 healthy participants will be enrolled for 3 study visits and on study for up to 12 weeks.
Description
Double-blind crossover study design. Healthy volunteers will attend three study drug administration visits, at least 7 days apart, in which methamphetamine isomer pharmacology will be assessed following intravenous administration of (1) S-(+)-methamphetamine, (2) R(-)-methamphetamine, or (3) a (1:1) racemic mixture of R-(-)- and S-(+)-methamphetamine. The order of these interventions will be counterbalanced across participants. Serial blood samples will be drawn during each dosing visit and compared with concurrent dried blood spots from a finger stick, oral fluid collections, and pooled urine…
Eligibility
- Age range
- 21–64 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Good mental health as determined by self-reported responses to the Psychopathology Screener * Absence of any major cardiac, neurologic, psychiatric, oncologic, endocrine, metabolic, renal, or hepatic disease as determined by self-reported responses to the Medical History Screener * English-speaking (able to provide consent and complete questionnaires) * Written Informed Consent Exclusion Criteria: * Any serious prior adverse response to sympathomimetic agents or amphetamine analogs * History of or current substance use disorder as determined by self-reported responses…
Interventions
- DrugS-(+)-methamphetamine
15 mg
- DrugR-(-)-methamphetamine
15 mg
- Drug1:1 racemic mixture of two isomers
15 mg R-Meth + 15 mg S-Meth
Location
- University of WisconsinMadison, Wisconsin