Adjuvant Ablation for PeRsistent AtrIal FibrillAtion Using Dual ENergy LatticE Tip Catheter: ARIADNE-Randomized Clinical Trial
Stavros E Mountantonakis
Summary
A prospective multi-arm parallel group randomized clinical trial to compare the efficacy of three ablation strategies in patients with persistent atrial fibrillation using using a lattice-tip catheter that can switch between RFA and PFA energy. The incremental benefit of posterior wall isolation (PWI) and mitral isthmus ablation may contribute to greater freedom from atrial fibrillation at twelve months.
Description
This is a prospective randomized clinical trial. Patients will undergo catheter ablation for persistent AF using a lattice-tip catheter that can switch between RFA and PFA energy. Enrolled patients will be randomized to one of three ablation strategies: 1. Pulmonary vein isolation using PFA energy 2. Pulmonary vein isolation and posterior wall isolation using PFA energy 3. Pulmonary vein isolation and posterior wall isolation (PFA) and mitral isthmus ablation using RFA or PFA energy. Patients will receive an implantable loop recorder prior to, during or post index ablation procedure for cont…
Eligibility
- Age range
- 18–80 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1\. Symptomatic PerAF documented by (1a) a physician's note indicating symptoms consistent with AF sustained longer than 7 days but less than 12 months; AND electrocardiographic evidence 2\. . Suitable candidate for catheter ablation. 3\. . Adults aged 18 - 80 years. 4\. . Willing and able to comply with all baseline and follow-up evaluations for the full length of the study. Exclusion Criteria: 1. AF secondary to electrolyte imbalance, thyroid disease, acute alcohol intoxication, or other reversible or non-cardiac cause. 2. Previous left atrial ablation or surgical…
Interventions
- ProcedureCatheter Ablation
This is a prospective randomized clinical trial. Patients will undergo catheter ablation for persistent AF using a lattice-tip catheter that can switch between RFA and PFA energy. Enrolled patients will be randomized to one of three ablation strategies:
Locations (3)
- North Shore University HospitalManhasset, New York
- Long Island Jewish Medical CenterNew Hyde Park, New York
- Kristie ColemanNew York, New York