Research Investigating Drug Effects-2 (RiDE-2)
University of Illinois at Chicago
Summary
The purpose of this study is to better understand how people's mood, behavior, and brains respond to different recreational drugs. We are also trying to understand why some people may feel differently or their brain may respond differently than other people after taking the same recreational drug.
Eligibility
- Age range
- 18–21 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * age 18-21 at eligibility visit * body mass index of 18.5-30 * report using cannabis ≥10 times in their life and ≥1 time in the past 3 months, but \<7 days a week (daily) * medically and neurologically healthy * score of ≥0.25 on the Personality Inventory for DSM-5 (PID-5) Anhedonia subscale Exclusion Criteria: * positive urine drug screen (UDS; except for THC) and/or positive saliva THC test * contraindication for fMRI BOLD study (e.g., metal implants) * severe mental illness (e.g., psychosis, mania, lifetime moderate-to-severe SUD (including moderate-to-severe CUD)) *…
Interventions
- DrugPlacebo Oral Capsule
A capsule that contains only dextrose filler administered during the first or second laboratory visit.
- DrugTHC
A capsule that contains 7.5 mg of THC as well as dextrose filler administered during the first or second laboratory visit.
Location
- University of Illinois at ChicagoChicago, Illinois