Memorial Sloan Kettering Cancer Center
The researchers are doing this study to find out if the study treatment is an effective treatment that causes few or mild side effects in people with diffuse large B-cell lymphoma (DLBCL), high-grade B-cell lymphoma (HGBCL), or transformed lymphoma. The treatment being tested in this study is glofitamab, polatuzumab, and obinutuzumab in combination with standard treatment (the combination of rituximab, cyclophosphamide, doxorubicin, and prednisone, or R-miniCHP).
Inclusion Criteria: 1. Age 65-79 years with a fitness assessment of unfit or frail per simplified GA (Appendix 1, www.filinf.it/epi) 2. Age ≥80 years with any fitness level 3. Pathologically confirmed DLBCL, HGBCL or transformed lymphoma 4. No prior systemic anti-lymphoma therapy (prednisone/equivalent up to 100 mg daily x 7 days is permissible) 5. Ann Arbor Stage 2 bulky, 3 or 4 disease (Appendix 1) 6. Any IPI score (Appendix 1) 7. Anthracycline eligible: LVEF ≥ 45% by echocardiogram or MUGA scan. 8. Must have at least one bi-dimensionally measurable lesion (\>1.5 cm in its largest dimension…
C1D8 2.5 mg iv; C1D15 10 mg iv; C2D1-onwards: 30 mg iv, every 3 weeks
1.8 mg/kg iv C1D1 onwards, every 3 weeks
375 mg/m2 iv D1
400 mg/m2 iv D1
25 mg/m2 iv D1
1000 mg iv C1D1 (7 days prior to glofitamab administration) single dose