Investigation of Psychedelic Effects in Psychoactive Substances

Summary

The aim of this double-blind, placebo-controlled, within-subjects study is to determine whether other psychoactive substances can produce experiences akin to those seen with classic psychedelics. Screening involves a medical and psychiatric examination, including blood draw, history and physical, interviews, and questionnaires. Eligible participants will then be asked to complete up to 6 experimental drug administration session during which the participants will potentially receive and report on the subjective effects of 6 different psychoactive substances or inactive placebo. Drug assignment for some sessions will be randomized (like flipping a count or rolling a pair of dice), and both participants and study staff will be blind to the drug condition on any given day. Participants will also complete 2 preparation sessions (4 hours total) before the first experimental session, and follow-up visits after each session to discuss and debrief on the participants subjective experience.

Eligibility

Age range

25–55 years

Sex

All

Healthy volunteers

Yes

Interventions

• Drug
  Placebo

  inactive substance

• Drug
  Psilocybin

  active comparator for psychedelic effects

• Drug
  Ketamine

  psychoactive substance

• Drug
  Dextromethorphan (DXM)

  psychoactive substance

• Drug
  Dimethyltryptamine (DMT)

  psychoactive substance

• Drug
  Methylenedioxymethamphetamine (MDMA)

  psychoactive substance

• Drug
  Tetrahydrocannabinol (THC)

  psychoactive substance

Location