University of Colorado, Denver
This study is being done to the determine the ability and utility of using the Neuropixels probes in the human brain. A Neuropixels probe will be inserted into and removed from the brain of awake human patients who are undergoing awake Deep Brain Stimulation (DBS) surgery.
This project aims to use Neuropixels probes to record hundreds of neurons during awake human intracranial surgeries. Using this probe, we will take advantage of access to a key area in the network involved in executive function, the middle frontal gyrus of the dorsal lateral Pre Frontal Cortex (approximately the mid portion of dlPFC, part of Brodmann area 9/46), to test emerging concepts that cognitive flexibility so crucial to human EF is encoded in neural population geometry and layer-specific interactions.
Inclusion Criteria: 1. Diagnosis of Parkinson's disease and refractory to medications requiring deep brain stimulation 2. Aged 45-85 3. Able to provide informed consent 4. Normal neuropsychiatric evaluation that includes tests of executive function demonstrating no greater than mild impairments, within expectation for Parkinson's disease. 5. Medically able to undergo deep brain stimulation surgery as evaluated by study neurosurgeon. 6. Surgical plan includes an entry point that can safely be placed in the dorsal lateral PFC. 7. Able to tolerate awake deep brain stimulation surgery with a plan…
The Neuropixels probe (imec, Leuven, Belgium) is a new high resolution multi electrode technology that uses custom 130-nm complementary metal-oxide-semiconductor fabrication with high surface area but low-impedance titanium nitride recordings to produce high site count devices with extreme electrode density in a small package.
Show that Neuropixels can safely and effectively record from large populations of neurons.
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