Diabetes Prediction During Pregnancy Using Pancreas MRI
University of Texas at Austin
Summary
Previous studies have shown that pancreas size tends to be smaller in individuals with diabetes compared to those without diabetes. The investigators have recently found that pancreas size increases during pregnancy. The MAMA study aims to examine changes in the pancreas that occur during pregnancy, in both pregnant mothers and their babies, and find out how they are affected by maternal diabetes. The MAMA study is a prospective cohort study that will follow women and their babies through pregnancy and one year postpartum. Women aged 18-54, who are under 14 weeks pregnant are being recruited to participate in the MAMA study.
Description
As pancreas size is thought to reflect pancreatic insulin production and/or islet mass, monitoring pancreas size during and after pregnancy may advance the investigators' understanding of gestational diabetes mellitus (GDM) incidence and progression. Information on pancreas size changes during pregnancy, typical fetal pancreatic development, the relationship between pancreas size and GDM risk, and the relationship between pancreas size and neonatal hypoglycemia are largely unknown. Through this project, magnetic resonance imaging (MRI) will be used to measure changes in pancreas size during pr…
Eligibility
- Age range
- 18–54 years
- Sex
- Female
- Healthy volunteers
- Yes
Inclusion Criteria: * Pregnant women, with a singleton gestation * Age 18 - 54 years at screening * Gestational age \< 14 weeks * Willing to commit to 1 year postpartum follow up * Planning to remain in geographical vicinity of Austin for 1 year after delivery Exclusion Criteria: * Presence of any mechanically or magnetically activated implants * Claustrophobia * Other contraindication for MRI * BMI ≥ 38.0 or maximum width less than 48 cm (necessary to fit within the MRI field of view)
Interventions
- OtherNo intervention
Observational study
Location
- Dell Medical School Health Discovery BuildingAustin, Texas