Sympathetic Vascular Transduction Across the Menopause Transition: Contributing Mechanisms
University of Missouri-Columbia
Summary
The investigators aim to assess the interactions between the sympathetic nervous system and the vasculature in women across the menopause transition to better understand why aging women have a higher risk of cardiovascular disease.
Eligibility
- Age range
- 18–70 years
- Sex
- Female
- Healthy volunteers
- Yes
Inclusion Criteria: * Assigned female at birth * 18-70 years of age * Body mass index (BMI) \<30 kg/m2 Exclusion Criteria: * Assigned male at birth * Pregnancy, breastfeeding * Body mass index ≥30 kg/m2 * Oral hormonal contraception in last 6 months, history of hormone replacement therapy, oophorectomy * Current smoking/nicotine use * Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy * Nerve/neurologic disease * Cardiovascular, hepatic, renal, respiratory disease * Blood pressure ≥140/90 mmHg * Diabetes, Polycystic ovarian syndrome * Communicat…
Interventions
- DrugPropranolol Hydrochloride
Examine how IV propranolol impacts sympathetic transduction
- DrugPhentolamine Injection
Examine how IV phentolamine impacts sympathetic transduction
Location
- University of MissouriColumbia, Missouri