The Cleveland Clinic
Aortic aneurysm patients benefit from exercise yet patients and physicians do not know a safe level. Cardiac MRI (CMR) is the most comprehensive imaging modality for phenotypic evaluation of patients with cardiac disease but it has not been used to study aneurysm patients. The purpose of this project is use exercise CMR to understand regional aortic function and quantify aortic elasticity in these populations while exercising. This project will correlate the exercise CMR data with the biomechanical properties of the patient's aortic tissue, including epiaortic ultrasound and TEE performed during aortic repair, and explanted aortic specimens subjected to ex vivo uniaxial tensile testing. Correlating this data with aortic response to exercise will allow us to understand how aortic size, in vivo circumferential strain values, ex vivo aortic efficiency and mechanical failure all relate to exercise physiology.
Engaging in regular exercise in controls lowers blood pressure over time, and this is associated with a lower risk of future aortic complications. However, it is not known what level of exercise is safe for aneurysm patients. Cardiac MRI (CMR) is the most comprehensive imaging modality for phenotypic evaluation of patients with cardiac disease. It has been limited in its use because exercise stress MRI is not widely available due to the need for MRI safe exercise equipment. However, the Cleveland Clinic has purchased a Lode MRI compatible exercise ergometer that is FDA approved and compatible…
Inclusion Criteria: 1. Healthy controls for baseline comparison 1. Must be 18 years or older 2. No history of cardiovascular disease, neither hypertension, diabetes nor hypercholesterolemia 2. Aneurysm patients who have not yet been operated on but are currently being monitored 1. Must be 18 years or older 2. No history of operation for aortic aneurysm 3. Pre-operative aneurysm patients: imaged pre-operatively and 12 months 1. Patients admitted at the CCF cardiothoracic services for elective surgery due to aortic aneurysms 2. Must be 18 years or older Exclusion Criteria:…
Exercise stress MRI with ergometer
Arctuva estimate
Verify or correct the compensation shown for this listing.