Stenting for Ischemic Strokes Secondary to Medically Refractory Intracranial Atherosclerotic Disease: STRICT-ICAS
Nitin Goyal
Summary
The goal of this observational study is to establish a prospective multicenter registry of patients undergoing intracranial stenting for ischemic strokes caused by medically refractory ICAD. The study aims to evaluate current practice patterns, periprocedural outcomes, and delayed outcomes. Researchers will collect demographic and procedural data from patients who undergo intracranial stenting after having an ischemic stroke caused by medically refractory ICAD.
Description
Background: Intracranial atherosclerotic disease (ICAD) accounts for approximately 10% of ischemic strokes in the United States and is a major cause of recurrent strokes. Although three randomized controlled trials (RCT) have failed to show the benefit of endovascular treatment \[1-3\], there exists a subset of patients who experience recurrent strokes despite maximum medical therapy. These patients may benefit from Percutaneous Angioplasty and Stenting (PTAS), especially when selecting flow-related stroke subtypes rather than perforator or embolic strokes or patients with recurrent transient…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Adult patients with ICAD resulting in 70-99% vessel stenosis who undergo PTAS with any device * Patients will have to experience a stroke despite medical management involving risk factor modification and an antiplatelet agent * Baseline modified Rankin Scale (mRS) ≤ 3 * Performance of the endovascular procedure at least 3 days after the last stroke Exclusion Criteria: * Large vessel occlusion strokes undergoing rescue intracranial stenting will not be included * Baseline modified Rankin Scale (mRS) \>3 * Performance of the endovascular procedure less than 3 days after…
Location
- Semmes Murphey ClinicMemphis, Tennessee