Hospital for Special Surgery, New York
Complex Regional Pain Syndrome (CRPS) is an orphan condition with no interventions proven effective in large-scale clinical trials. In-person clinical evaluations are required to make a CRPS diagnosis and determine study eligibility, making recruitment for CRPS trials challenging. To address this barrier, we will validate a self-report measure of CRPS symptom severity suitable for remote administration that was created by colleagues at Vanderbilt University. The aim of this study is to evaluate the correspondence at the item and total score level between the proposed self-report measure (CRPS Severity Score-Self Report; CSS-SR) and an existing validated measure of CRPS signs and symptoms derived from clinical history and physical examination data (CSS-Clinician version) and evaluate its diagnostic accuracy relative to clinically determined, criterion-based CRPS diagnosis using the Budapest criteria.
Complex Regional Pain Syndrome (CRPS) is a chronic pain condition characterized by spontaneous pain, allodynia and hyperalgesia, edema, vasomotor and sudomotor changes, and motor and trophic changes. It usually begins regionally in a single limb after injury or surgery, and inflammatory, autonomic, and central mechanisms all appear to contribute to differing degrees. There are currently no treatments for CRPS proven effective in large scale clinical trials. CRPS is considered an orphan condition by the U.S. Food and Drug Administration, and as such, acquiring adequate sample sizes for definit…
Inclusion Criteria: * 18 years of age or older * Suspected or diagnosed with unilateral CRPS type I or II of the upper or lower extremity * Suspected or diagnosed with non-CRPS-related pain of the upper or lower extremities Exclusion Criteria: * Bilateral CRPS * Total knee arthroplasty as the inciting event of CRPS * Less than 18 years of age * Non-English speaking * Inability to comprehend study protocol and questionnaires
Self-report tool in a questionnaire format to capture CPRS Severity Score.
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