Sildenafil to Prevent and Reduce Cancer Related Cognitive Impairment
The University of Texas Medical Branch, Galveston
Summary
This study is examining the effects of standard of care cancer treatment as well as a medication called Sildenafil, on the cancer associated fatigue, cognition and the gut microbiome.
Description
Cancer related cognitive impairment (CRCI) severely impacts neurocognitive function and is characterized by deficits in memory, learning, processing speed, and executive function. This cognitive impairment commonly referred to as "brain fog" or "chemo-brain," often co-occurs with central and peripheral fatigue. Symptoms typically begin acutely with the initiation of therapy, and persist chronically throughout prolonged treatment. Despite advancements in cytotoxic chemotherapies, CRCI plagues 75% of breast cancer patients during treatment, and development of new therapeutic options have been ha…
Eligibility
- Age range
- 30–50 years
- Sex
- Female
- Healthy volunteers
- No
Inclusion Criteria: * Female * Ages 30 - 50 years * Self-reported menses occurrence within past 12 months * Diagnosis of ER+/HER2- breast cancer * Willing and able to comply with study procedures * Willing and able to provide consent Exclusion Criteria: * Untreated thyroid disorder * Untreated diabetes * BMI \>30 * Current treatment with metformin * Diagnosed neuromuscular disease * Diagnosed neurovascular disease * Prior history of cognitive impairment * Prior history of chemotherapy treatment * HIV, Hepatitis B or Hepatitis C * Systolic blood pressure \<90 or \>170, diastolic blood pressu…
Interventions
- DrugSildenafil
Sildenafil, 50mg, daily
Location
- The University of Texas Medical BranchGalveston, Texas