Vaping and Vagal Neuromodulation of Cognition
Temple University
Summary
The purpose of this study is to assess the effects of non-invasive vagus nerve stimulation (nNVS) on cognitive functioning in the users of e-cigarettes or vaping products. The investigators will use a digital wellness companion product (TRUVAGA™ device) that provides mild transcutaneous nVNS. The participants will be randomized to receive either a 2-min nNVS stimulation or control stimulation in the neck region followed by completion of three cognitive tests of attention and executive function.
Description
Electronic cigarettes, also referred to as e-cigarettes or vapes were initially developed as a smoking cessation tool and considered less harmful, but the presence of nicotine in the vapes make them highly addictive. The use of E-cigarettes has dramatically increased among the youth and young adults in the last decade. While the risks associated with traditional, combustible cigarette smoking are "well-established," vaping also exposes individuals to nicotine which is highly addictive and it can have long-term detrimental effects on the brain. Impairments in cognitive processes including atten…
Eligibility
- Age range
- 18–25 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Healthy young adults * Age range 18-25 years * Current or prior users of e-cigarettes Exclusion Criteria: Participants will be excluded from the study if they: * Have any rash, infection, swelling, cut, soreness, drug patch, surgical scar on the neck area * Have any implantable medical device in their body such as a pacemaker, hearing aid implant, or any other metallic/electronic device * Have any hearing or vision problems that are not corrected * Are pregnant or breastfeeding * Have any learning disabilities * Have a medical history of any of the following condition…
Interventions
- DeviceActive nVNS
2-min transcutaneous nVNS stimulation using portable Truvaga Plus Device (electroCore Inc., Rockaway, NJ).
- DeviceControl nVNS
2-min control stimulation using portable Truvaga Plus Device (electroCore Inc., Rockaway, NJ).
Location
- Temple UniversityPhiladelphia, Pennsylvania