Residual Gastric Content and GLP-1
University of Arkansas
Summary
Studies have shown that even following the fasting guideline, patients on GLP-1 still have residual gastric content which increases their risk of aspiration during anesthesia. We aim to investigate the prevalence of full stomachs following different fasting times.
Description
Glucagon-like peptide-1 (GLP-1) receptor agonists have become increasingly popular as both diabetic and weight loss therapies. One effect of this class of medication is delayed gastric emptying, which may impact the risk of aspiration during anesthesia delivery. Some of them have a very long half-life of approximately one week. Thus, it takes approximately five weeks to achieve its steady-state concentration, and just as long for its effects to terminate after stopping the drug. As a standard of care, patients are allowed to drink up to 2 hours and to eat up to 8 hours before surgery. Studies…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: Age ≥ 18 yr. ASA physical status I- III Elective surgery Exclusion Criteria: * Pregnancy * History of upper gastrointestinal disease or previous surgery on the esophagus, stomach or upper abdomen; * Documented abnormalities of the upper gastrointestinal tract such as gastric tumors; recent upper gastrointestinal bleeding (within the preceding 1 month). * Medicines that may delay gastric emptying (e.g., anticholinergic agents, opioid) * ASA class IV or above * Unable to understand English * Cardiac cases with low ejection fraction * Elderly patients above 65 years of age…
Location
- University of Arkansas for Medical ScienceLittle Rock, Arkansas