Resting Indicators of Vascular Health and Cardiovascular Reactivity in Females With "Normal-Weight Obesity"
Ball State University
Summary
Most of the time, body weight is evaluated by looking at the ratio of your weight to your height. This measurement is called body mass index or BMI. However, BMI does not account for what your body is actually made up of (e.g., body fat versus muscle), which may be more important for determining cardiovascular disease risk. The investigators aim to understand vascular health in females with a "healthy" BMI with differing amounts of body fat and muscle mass. We will have participants come to the lab for two different study visits. At one visit, participants will eat a meal high in fat, and at the other visit, participants will undergo a stress task.
Description
The investigators will recruit females with a BMI in the normal (18.5-24.9 kg/m2) from the Ball State University campus and surrounding communities. Each participant will complete a meal trial and a stress trial in a randomized crossover design. At the meal trial, an intravenous catheter will be inserted and baseline blood sample collected. Then vascular measurements (i.e., flow-mediated dilation, pulse wave analysis, pulse wave velocity) will be performed. Each time vascular measurements are performed, the participants will lie in a quiet area to acclimate prior to beginning. Next, participan…
Eligibility
- Age range
- 18–50 years
- Sex
- Female
- Healthy volunteers
- Yes
Inclusion Criteria: * You are 18-50 years old * Your biological sex is female * BMI is in "normal" category (18.5-24.9 kg/m2) - this BMI requirement is due to our research aims * You are not pregnant or expecting to become pregnant * You are not postmenopausal * You have not been diagnosed with a cardiometabolic condition (e.g., cardiovascular disease, type 2 diabetes) * You have not been diagnosed with a chronic inflammatory condition (e.g., rheumatoid arthritis, inflammatory bowel disease). * You do not regularly take anti-inflammatory drugs (more than 2x week) or are able to temporarily su…
Interventions
- Otherhigh-fat meal
Participants will report fasted and consume two Jimmy Dean breakfast bowls (sausage).
- OtherStress
Participants will report fasted and undergo a mental stress task.
Location
- Ball State University- Nutrition Assessment LabMuncie, Indiana