Effects of Dietary Wild Blueberries on Gut Health and Inflammation and Joint Pain
University of Nevada, Las Vegas
Summary
The goal of this proposed study is to examine the effects of dietary wild blueberries on gut microbiome, serum markers of inflammation, and joint function in adults. Each participant will consume 25g freeze-dried blueberries or matched placebo powder for 12 weeks, with a 2-week washout phase between.
Eligibility
- Age range
- 40–75 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Adults with documented multi-joint/knee arthritis Exclusion Criteria: * inability to give informed consent * pregnancy or lactation * planned knee replacement surgery * allergy or contraindication to berries * recent trauma of the knee responsible of the symptomatic knee * intra-articular injection in the target knee/hip in the last 3 months * oral corticosteroid therapy ≥ 5 mg/day (prednisone equivalent) at baseline * use of berry extracts in the last 3 months * special diets * cancer treatment * bone diseases
Interventions
- Dietary SupplementWild blueberry
Freeze-dried wild blueberry powder 25g/day
- Dietary SupplementPlacebo
Placebo powder matched for calories and no polyphenols
Location
- OMRFOklahoma City, Oklahoma